Centre d’Élaboration de Matériaux et d’Etudes Structurales (UPR 8011)


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Conference from Prof. Kazushi Kinbara

Tokyo Institute of Technology

"Multiblock amphiphilic molecules mimicking structure and function of membrane proteins."

Kazushi Kinbara
School of Life Science and Technology, Tokyo Institute of Technology
Address : B-58, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan
E-mail : kkinbara chez bio.titech.ac.jp

 

Synthetic molecules mimicking the structure and function of proteins gain increasing importance for development of molecular devices and medicines. Membrane proteins are important targets due to their unique functions such as ion transportation and stimuli responsiveness. As simple structural mimics of membrane proteins, we designed multiblock molecules, consisting of linearly connected hydrophilic oligoethylene glycol units and hydrophobic aromatic units. We found that the hydrophobic units of these molecules form stacking in the membrane, to give folded structures and allow permeation of ions through the membranes. This molecular design principle also allowed us to develop stimuli-responsive materials exhibiting unique phase transition behaviors. The properties of these molecules will be presented.

 

[1] T. Muraoka, T. Shima, T. Kajitani, N. Hoshino, E. Morvan, A. Grélard, E. J. Dufourc, T. Fukushima, T. Akutagawa, K. Nabeya, and K. Kinbara, Chem. Asian J. 2019, 14, 141–148.

[2] T. Muraoka, K. Umetsu, K. Tabata, T. Hamada, H. Noji, T. Yamashita, and K. Kinbara, J. Am. Chem. Soc. 2017, 136, 15584–15595.

[3] T. Muraoka and K. Kinbara, Chem. Commun. 2015, 51, 8457–8460 (Feature Article).

[4] T. Muraoka, T. Endo, K. V. Tabata, H. Noji, S. Nagatoishi, K. Tsumoto, R. Li and K. Kinbara, J. Am. Chem. Soc. 2014, 136, 15584–15595.

[5] T. Muraoka, T. Shima, T. Hamada, M. Morita, M. Takagi, K. V. Tabata, H. Noji, and K. Kinbara, J. Am. Chem. Soc. 2012, 134, 19788–19794.

[6] T. Muraoka, T. Shima, T. Hamada, M. Morita, M. Takagi, K. V. Tabata, H. Noji, and K. Kinbara, Chem. Commun. 2011, 47, 194–196.

 

 

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