History and past achievements
In early 2000, the team has developed a new process, based on spray pyrolysis, to elaborate luminescent nanoparticles in partnership with the startup DGtech and the French TV manufacturer Thomson Plasma. Unfortunately, these two companies went bankrupt in 2006 and 2007. Consequently, to finalize the valorization of all our work, the team actively participated to the creation in 2008 of the spin-off PYLOTE who developed the spray pyrolysis process upto an industrial stage. The collaboration between the NanoPro team and the company was very active from 2008 to 2012, when the team is involved in another project while pursuing an expertise and service activity for PYLOTE company which now flies on his own.
More particularly specializing in luminescent nanoparticles based on lanthanides, the team is behind the creation in 2013 of a new spin-off called CHROMALYS. This startup, currently housed in the same building as the CEMES, designs, manufactures and markets new multimodal nano-probes for biological, preclinical and later, medical imaging, allowing luminescence detection, X-ray tomography and MRI. ChromaLys targets two goals. Growing rapidly on preclinical imaging market (for laboratory animals) then developing its expertise for a human clinical application for Image Guided Radiation Therapy (IGRT).
Since 2014 NanoPro team has worked closely with ChromaLys company following a task division according to the mission of each partner. For NanoPro team the development, upstream, of new multimodal and more efficient probes. For the company, production process rationalization, implementation of end-users tests and all aspects of business development. Of course, this works in symbiosis, leads to common publications and patent deposits.
Currently our team is more particularly involved in the development of new luminescent probes, working in the near infrared, and detectable by time gated detection. That allows a large improvement of the signal to noise ratio, both on photonic microscopy as for in vivo imaging.
Besides, since 2015, our team, in association with the university of Parakou, takes advantage of its experience and expertise, for the elaboration and the multiscale study of different depolluting materials formed from clays (such as kaolin or smectite).
This emergent activity of our team is the result of an increasing need for new materials, limiting the environmental impact of human activities, defined as a goal within the framework of sustainable development and of the social responsibility.
Our first results demonstrate the relationship between natures and morphologies of our materials and their ability to adsorb some commons pollutants, such as those classically present in agricultural effluents.
Today, the objectives of our research are the understanding of the mechanisms involved for each synthetized material, and the forming of optimized and fully recyclable depolluting supports easily implemented on an industrial scale, within the framework of an eco-responsible process.
This cross-cutting activity is jointly driven by Robert MAURICOT (M3 Group), David NEUMEYER (Characterization pole) and Semiyou Ayélé OSSENI (Parakou University-USATN).
Some recent publications and patents
- Lixin Zhang, Xianlin Zheng, Wei Deng, Yiqing Lu, Severine Lechevallier, Zhiqiang Ye, Ewa M Goldys, Judith M Dawes, James A Piper, Jingli Yuan, Marc Verelst, Dayong Jin « Practical Implementation, Characterization and Applications of a Multi-Colour Time-Gated Luminescence Microscope” NATURE SCIENTIFIC REPORTS, 4, 6597, 2014
- Semiyou A Osseni, Sévérine Lechevallier, Marc Verelst, Pascal Perriat, Jeannette Dexpert-Ghys, David Neumeyer, Robin Garcia, Florian Mayer, Kristina Djanashvili, Joop A Peters, Eddy Magdeleine, Hélène Gros-Dagnac, Pierre Celsis, Robert Mauricot « Gadolinium oxysulfide nanoparticles as multimodal imaging agents for T_2 weighted MR, X-ray tomography and photoluminescence » Nanoscale. 2014 Jan 7 ;6(1):555-64.
- Caroline Cassia Alves, Julien Demoucron, Bruno Caillier, Phillipe Guillot, Robert Mauricot, Jeannette Dexpert-Ghys, José Mauricio Almeida Caiut « Amino acid coupled to Pr3+ doped lanthanum orthophosphate (LaPO4) nanoparticles » Matrials Letters 137 (2014) 435-439
- Dexpert-Ghys, Jeannette ; Mauricot, Robert ; Caillier, Bruno ; Guillot, Philppe ; Beaudette, Tristan ; Jai, Guohua ; Tanner, Peter ; Cheng, Bing-Ming « VUV Excitation YBO3 and (Y,Gd)BO3 Phosphors doped with Eu3+ or Tb3+ : comparison of efficiencies and Effects of site-selectivity » Journal of Physical Chemistry C, (2010), 114, 6681-6689,
- Brevet FR 14 52 111 : Nanoparticules pour leur utilisation dans la détection de tumeurs mobiles
- Brevet FR 10 57296 : NANOPARTICULES LUMINESCENTES UTILISABLES EN TANT QUE MARQUEURS ET PROCEDE POUR LEUR PREPARATION